In 1840s London, Dr. Thomas Bolton [Boris Karloff] dares to dream the unthinkable: experimenting with anesthesia gases to make surgery pain-free. While doing so, his demonstration before a panel of his peers ends in a horrific mishap with his patient awakening under the knife; he is forced to leave his position in disgrace. To complicate matters, he becomes addicted to his own chemical experiments and gets involved with a criminal gang led by Black Ben [Francis de Wolff], and a ruthless killer Resurrection Joe [Christopher Lee]. Unfortunately, this shady partnership leads Dr. Bolton to further ruin, culminating in his unwitting participation in murder — for which he becomes the first victim of a blackmail scheme.
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| Editing | Peter Mayhew | Editor |
| Directing | Robert Day | Director |
| Camera | Geoffrey Faithfull | Director of Photography |
| Writing | Jean Scott Rogers | Screenplay |
| Art | Anthony Masters | Art Direction |
| Costume & Make-Up | Wally Schneiderman | Makeup Artist |
| Production | Charles F. Vetter | Producer |
| Production | John Croydon | Producer |
| Production | Richard Gordon | Executive Producer |
| Production | Peter Mayhew | Associate Producer |
| Sound | Buxton Orr | Original Music Composer |
| Directing | Peter Bolton | Assistant Director |
| Costume & Make-Up | Eileen Warwick | Hairstylist |
| Crew | Maurice Askew | Sound Recordist |
| Production | George Mills | Production Manager |
| Directing | Michael Stevenson | Third Assistant Director |
| Directing | Susan Dyson | Continuity |
| Sound | Cyril Swern | Sound Recordist |
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